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Exam Code: MCAT
Exam Questions: 815
Medical College Admission Test: Verbal Reasoning, Biological Sciences, Physical Sciences, Writing Sample
Updated: 21 Feb, 2026
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Question 1

Four major blood types exist in the human ABO blood system: types A, B, AB, and O; and there are three
alleles that code for them. The A and B alleles are codominant, and the O allele is recessive. Blood types are
derived from the presence of specific polysaccharide antigens that lie on the outer surface of the red blood cell
membrane. The A allele codes for the production of the A antigen; the B allele codes for the production of the B
antigen; the O allele does not code for any antigen.
While there are many other antigens found on red blood cell membranes, the second most important antigen is
the Rh antigen. Rh is an autosomally dominant trait coded for by 2 alleles. If this antigen is present, an
individual is Rh+; if it is absent, an individual is Rh−. For example, a person with type AB blood with the Rh
antigen is said to be AB+.
These antigens become most important when an individual comes into contact with foreign blood. Because of
the presence of naturally occurring substances that closely mimic the A and B antigens, individuals who do not
have these antigens on their red blood cells will form antibodies against them. This is inconsequential until
situations such as blood transfusion, organ transplant, or pregnancy occur.
Erythroblastosis fetalis is a condition in which the red blood cells of an Rh+ fetus are attached by antibodies
produced by its Rh− mother. Unlike ABO incompatibility, in which there are naturally occurring antibodies to
foreign antigens, the Rh system requires prior sensitization to the Rh antigen before antibodies are produced.
This sensitization usually occurs during the delivery of an Rh+ baby. So while the first baby will not be harmed,
any further Rh+ fetuses are at risk.
The Coombs tests provide a method for determining whether a mother has mounted an immune response
again her baby’s blood. The tests are based on whether or not agglutination occurs when Coombs reagent is
added to a sample. Coombs reagent contains antibodies against the anti-Rh antibodies produced by the
mother. The indirect Coombs test takes the mother’s serum, which contains her antibodies but no red blood
cells, and mixes it with Rh+ red blood cells. Coombs reagent is then added. If agglutination occurs, the test is
positive, and the mother must be producing anti-Rh antibodies. The direct Coombs test mixes the baby’s red
blood cells with Coombs reagent. If agglutination occurs, the test is positive, and the baby’s red blood cells
must have been attacked by its mother’s anti-Rh antibodies.
How might one most practically assess the risk of erythroblastosis fetalis in a pregnant woman?

Section: Biological Sciences 

Options :
Answer: C

Question 2

According to Piaget, which is the first stage of cognitive development?


Section: Biological Sciences 

Options :
Answer: A

Question 3

Gauguin's attitude toward art marked a break from the past and a beginning to modern art. Like all PostImpressionist artists, he passed through an Impressionist phase but became quickly dissatisfied with the
limitations of the style, and went on to discover a new style that had the directness and universality of a symbol
and that concentrated on impressions, ideas and experiences. The beginning of his modern tradition lay in his
rejection of Impressionism. He considered naturalism an error to be avoided. He was preoccupied with
suggestion rather than description, seeking to portray not the exterior, but the essence of things in their purest,
simplest, and most primitive form, which could only be achieved through simplification of the form. He firmly
believed throughout his life that “art is an abstraction” and that “this abstraction [must be derived] from nature
while dreaming before it.” One must think of the creation that will result rather than the model, and not try to
render the model exactly as one sees it. This was the birth of “Synthetism” or rather Synthetist-Symbolic, as
Gauguin referred to it, using the term “symbolic” to indicate that the forms and patterns in his pictures were
meant to suggest mental images or ideas and not simply to record visual experience.
Symbolism flourished around the period of 1885 to 1910 and can be defined as the rejection of direct, literal
representation in favor of evocation and suggestion. Painters tried to give a visual expression to emotional
experiences, and therefore the movement was a reaction against the naturalistic aims of Impressionism.
Satisfying the need for a more spiritual or emotional approach in art, Symbolism is characterized by the desire
to seek refuge in a dreamworld of beauty and the belief that color and line in themselves could express ideas.
Stylistically, the tendency was towards flattened forms and broad areas of color, and features of the movement
were an intense religious feeling and an interest in subjects of death, disease, and sin.
Similarly, “Synthetism” involved the simplification of forms into large-scale patterns and the expressive
purification of colors. Form and color had to be simplified for the sake of expression. This style reacted against
the “formlessness” of Impressionism and favored painting subjectively and expressing one's ideas rather than
relying on external objects as subject matters. It was characterized by areas of pure colors, very defined
contours, an emphasis on pattern and decorative qualities, and a relative absence of shadows.
Gauguin's new art form merged these two movements and succeeded in freeing color, form, and line, bringing
it to express the artists' emotions, sensibilities, and personal experiences of the world around them. His style
created a break with the old tradition of descriptive naturalism and favored the synthesis of observation and
imagination. Gauguin sustained that forms are not discovered in nature but in one's wild imagination, and it was
in himself that he searched rather than in his surroundings. For this reason, he scorned the Impressionists for
their lack of imagination and their mere scientific reasoning. Furthermore, Gauguin used color unnaturalistically
for its decorative or emotional effect and reintroduced emphatic outlines. “Synthetism” signified for him that the
forms of his pictures were constructed from symbolic patterns of color and linear rhythms and were not mere
scientific reproductions of what is seen by the eye.
Dempsey, A., & Dempsey, A. (2010). Styles, Schools and Movements: The Essential Encyclopaedic Guide to
Modern Art. London: Thames & Hudson.
Given the passage’s discussion of Synthetist-Symbolism, and some undiscussed remarks about how Japanese
art influenced Gauguin’s work, which of these features of Japanese painting can be reasonably assumed to
characterize Gauguin’s art form?

Section: Verbal Reasoning

Options :
Answer: A

Question 4

Band theory explains the conductivity of certain solids by stating that the atomic orbitals of the individual atoms
in the solid merge to produce a series of atomic orbitals comprising the entire solid. The closely-spaced energy
levels of the orbitals form bands. The band corresponding to the outermost occupied subshell of the original
atoms is called the valence band. If partially full, as in metals, it serves as a conduction band through which
electrons can move freely. If the valence band is full, then electrons must be raised to a higher band for
conduction to occur. The greater the band gap between the separate valence and conduction bands, the poorer
the material’s conductivity. Figure 1 shows the valence and conduction bands of a semiconductor, which is
intermediate in conductivity between conductors and insulators.
MCAT-part-1-page303-image150
Figure 1
When silicon, a semiconductor with tetrahedral covalent bonds, is heated, a few electrons escape into the
conduction band. Doping the silicon with a few phosphorus atoms provides unbonded electrons that escape
more easily, increasing conductivity. Doping with boron produces holes in the bonding structure, which may be
filled by movement of nearby electrons within the lattice. When a semiconductor in an electric circuit has
excess electrons on one side and holes on the other, electron flow occurs more easily from the side with
excess electrons to the side with holes than in the reverse direction.
MCAT-part-1-page303-image149
Figure 2
How does heat increase the conductivity of a semiconductor?
I) By reducing collisions between moving electrons
II) By breaking covalent bonds
III) By raising electrons to a higher energy level

Section: Physical Sciences 

Options :
Answer: D

Question 5

1

MCAT-patt-4-page313-image84
Figure 1
Myoglobin facilitates transport in muscle and serves as a reserve store of O2. Mb is a single polypeptide chain
containing a heme group, with a molecular weight of 18 kd. As can be seen in Figure 1, Mb (Curve D) has a
greater affinity for than Hb.
A sample of human adult Hb is placed in an 8 M urea solution, resulting in the disruption of noncovalent
interactions. After this procedure, the α chains of Hb are isolated. Which of the four curves most closely
resembles the O2-dissociation curve for the isolated α chains? [Note: Assume that Curve B represents the O2-
dissociation curve for human adult Hb in vivo.]

Section: Biological Sciences

Options :
Answer: D

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